Reference of 189281-66-1, Adding some certain compound to certain chemical reactions, such as: 189281-66-1, name is Methyl 2,6-dichloro-5-fluoronicotinate,molecular formula is C7H4Cl2FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 189281-66-1.
Description 111Methyl 2-chloro-5-fluoro-6-methylnicotinate (Dl 11)FXQN CIA mixture of methyl 2,6-dichloro-5-fluoronicotinate (DuO, 6 g), 2,4,6-trimethyl-1,3,5,2,4,6- trioxatriborinane (3.36 g), K2C03 (9.99 g) and Pd(Ph3P)4 (1.548 g) in 1,4-dioxane (50 mL) was heated to 110C for 20 hours. The mixture was filtered, and the filtrate was concentrated. The residue was purified by column chromatography (silica gel, petroleum ether/EtOAc = 10:1) toafford the title compound (3.5 g) as yellow oil. MS (ES1): C8H7C1FNO2 requires 203; found 204[M+H].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 189281-66-1, Methyl 2,6-dichloro-5-fluoronicotinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
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