As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19524-06-2, name is 4-Bromopyridine hydrochloride, molecular formula is C5H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 19524-06-2
General procedure: In a 10-mL glass tube were placed halide (1.0mmol); 2-formylphenyl or 2-pyridyl MIDA boronate (1.5mmol) or allyl MIDA boronate; K2CO3 (3.0 mmol); Pd EnCat30(6mol%); and ethanol/H2O (4:1v/v) or water, and a magnetic stir bar. The vessel was sealed with a septum and placed into the microwave cavity. The temperature was ramped from rt to 120C or 135C. Once the reaction temperature was reached, the reaction mixture was held at this temperature for 10-18 min. After the mixture was allowed to cool to room temperature, the reaction vessel was opened and the contents were poured into a separating funnel. Water and ethylacetate (3×10mL) were added. The combined organics were dried over Na2SO4, filtered, and concentrated in vacuo. The organic residue was adsorbed onto silicagel, and then purified by column flash chromatography (hexane = ethyl acetate as eluent) to afford the desired product 1a-x. The biaryls, bipyridines, or allylphenols prepared are known compounds. [23-45] The products were confirmed by comparing the 1H NMR and mass spectral data with authentic samples reported in the literature.
With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.
Reference:
Article; Da Silva, Joaquim F. M.; Yepes Perez, Andres F.; De Almeida, Natalia P.; Synthetic Communications; vol. 45; 17; (2015); p. 1995 – 2004;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem