Adding a certain compound to certain chemical reactions, such as: 626-60-8, 3-Chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
General procedure: Biaryls 1; General Procedure for the Suzuki-Miyaura Couplingof Aryl ChloridesA stock solution of Pd source (2 mol%) with ligand (correspondingPd/L ratio) in freshly distilled CH2Cl2 (10 mL) was initially preparedwith continuously stirring at r.t. An array of Schlenk tubesequipped with a Teflon-coated magnetic stirrer bar were evacuatedand backfilled with N2 (3 cycles). The stock solution of Pd with ligand(0.5 mL, 0.1 mol% Pd, or please refer to the corresponding Pdloading from different entries) and Et3N (0.1 mL) were transferredto an array of Schlenk tubes via syringes. The diluted Pd complexsolution was stirred and warmed using a household hair drier forabout 1 to 2 min until the solvent started boiling. The solvent wasthen evaporated under high vacuum. Ar2BF3K (0.75 mmol, 1.5equiv) and base (1.5 mmol, 3.0 equiv) were added to an array ofSchlenk tubes. Each tube was carefully evacuated and backfilledwith N2 (3 cycles). Aryl chloride (0.5 mmol, 1.0 equiv) and H2O(1.5 mL) were added via syringe. This batch of Schlenk tube was resealedand magnetically stirred in a preheated 100 C oil bath. Afterthe completion of the reaction, the reaction tubes were allowed toreach r.t. EtOAc (~10 mL) and H2O (~3 mL) were added. The organiclayer was subjected to GC analysis. The filtrate was concentratedunder reduced pressure. The crude products were purified byflash column chromatography on silica gel (230-400 mesh) to affordthe desired product
At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-60-8, 3-Chloropyridine, and friends who are interested can also refer to it.
Reference:
Article; Yuen, On Ying; Wong, Shun Man; Chan, Kin Fai; So, Chau Ming; Kwong, Fuk Yee; Synthesis; vol. 46; 20; (2014); p. 2826 – 2832;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem