Adding a certain compound to certain chemical reactions, such as: 100910-66-5, 5-Methylnicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100910-66-5, blongs to pyridine-derivatives compound. category: pyridine-derivatives
To a solution of compound But-3-enenitrile (1.05 g, 15.74 mmol) in THF (30 mL) was added N2H4.H20 (0.826 g, 16.52 mmol) slowly at 0 C, and the resulting mixture was stirred room temperature for 16 hrs. Then to the reaction mixture was added 5 -methylnicotinaldehyde (2.0 g, 16.52 mmol). After stirring for 2.5 hrs, the reaction mixture was concentrated to dryness in vacuum. To the residue in n-Butanol (30 mL) was added MeONa (0.85 g, 15.74 mmol), and the mixture was heated to 120 C for 16 hrs. The reaction mixture was poured into iN HC1 (50 mL), and the mixture was extracted with EtOAc (100 mL x2). The aqueous layer was basified to pH = 14 and extracted with EtOAc (100 mL x2). The extracts were dried over Na2SO4, filtered and concentrated to give 3-methyl-1-((5-methylpyridin-3-yl)methyl)-1H-pyrazol-5-amine (0.75 g, yield: 24%) as brown oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100910-66-5, its application will become more common.
Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; HASSIG, Christian, A.; JACKSON, Michael, R.; ARDECKY, Robert, John; PASS, Ian; (436 pag.)WO2016/123392; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem