Electric Literature of 499-51-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 499-51-4, name is 4-Hydroxypyridine-2,6-dicarboxylic acid. A new synthetic method of this compound is introduced below.
15 g of monohydric chelidamic acid (0.075 mol, I eq.) are dissolved in 120 mE of thionyl chloride under argon. The suspension is cooled to 00 C. and 3 mE DMF are added. The reaction mixture is then stirred for 12 hours with reflux. Volatiles are evaporated afier several toluene additions to remove the last traces of SOd2. The resulting yellowish solid is then dissolved in methanol and the mixture is refluxed for 12 hours to complete the reaction. After evaporation of the solvent, the residue is taken up by dichloromethane and washed successively with a saturated solution of NaHCO3, water and brine. The organic phase is then dried on Na2SO4, filtered and evaporated. Pure compound 12 is obtained by recrystallization in methanol to obtain 8.3of white crystalline powdet (R=44%). ?H-NMR (300 MHz, CDC13) oe (ppm)=8.29 (s,2H), 4.03 (s, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,499-51-4, its application will become more common.
Reference:
Patent; ECOLE NORMALE SUPERIEURE DE LYON; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE CLAUDE BERNARD LYON I; COMMISSARIAT A L’ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES; MAURY, Oliver; GIRARD, Eric; ENGILBERGE, Sylvain; RIOBE, Francois; (76 pag.)US2018/362550; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem