Analyzing the synthesis route of 53937-02-3

The synthetic route of 53937-02-3 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone, the common compound, a new synthetic route is introduced below. Recommanded Product: 53937-02-3

To a solution of Compound 11 (1 g, 4.97 mmol) in DMF (10 mL) was slowly added sodium hydride (219 mg, 5.47 mmol) under ice-cooling, and the obtained reaction mixture was stirred under ice-cooling for 45 minutes. Methyl 2-bromopropionate was added dropwise thereto, and the obtained reaction mixture was warmed up to room temperature and then stirred overnight. To the reaction liquid was added water, followed by extraction with ethyl acetate. The organic layer was washed twice with water and then dried with magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The concentrated residue was purified by silica gel column chromatography (hexane/ethyl acetate=1:1 to 1:4) to obtain Compound 12 (1.03 g, 72%) as a yellow solid. Compound 12; 1H-NMR (CDCl3) delta: 1.62 (3H, d, J=7.60 Hz), 3.75 (3H, s), 4.99 (2H, s), 5.54 (1H, q, J=7.44 Hz), 5.99 (1H, d, J=2.53 Hz), 6.04 (1H, dd, J=7.60, 2.53 Hz), 7.19 (1H, d, J=7.60 Hz), 7.35-7.40 (5H, m).

The synthetic route of 53937-02-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shionogi & Co., Ltd.; Kojima, Eiichi; Tonogaki, Keisuke; Tanaka, Nobuyuki; Katou, Manabu; Ino, Akira; Iwatsu, Masafumi; Fujioka, Masahiko; Hinata, Yu; Ohyabu, Naoki; (119 pag.)US9567330; (2017); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem