Adding a certain compound to certain chemical reactions, such as: 920979-04-0, 2-Iodo-6-(trifluoromethyl)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Iodo-6-(trifluoromethyl)pyridin-3-amine, blongs to pyridine-derivatives compound. Quality Control of 2-Iodo-6-(trifluoromethyl)pyridin-3-amine
A solution of 2-iodo-6-(trifluoromethyl)pyri din-3 -amine (1.1 g, 3.82 mmol), triethylamine (1.60 mL, 11.5 mmol), palladium (II) acetate (231 mg, 1.03 mmol), tri(o- toly)lphosphine (86 g, 2.06 mmol), and methyl prop-2-enoate (1.6 g, 18.59 mmol, 5.00 equiv) in acetonitrile (100 mL) stirred overnight at 90 C in an oil bath. The resulting mixture was concentrated under vacuum. The reaction was then quenched by the addition of 20 mL of water. The resulting solution was extracted with 3×30 mL of ethyl acetate, and the combined organic phases were washed with 50 mL of brine, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. The residue was purified via column chromatography on silica gel (eluting with 1 :3 ethyl acetate/petroleum ether) to give methyl (2E)-3-[3-amino-6- (trifluoromethyl)pyridin-2-yl]prop-2-enoate (900 mg, 96%) as a yellow solid. MS: (ESI, m/z): 247[M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,920979-04-0, 2-Iodo-6-(trifluoromethyl)pyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; FORMA THERAPEUTICS, INC.; ZHENG, Xiaozhang; MARTIN, Matthew W.; NG, Pui Yee; THOMASON, Jennifer R.; HAN, Bingsong; RUDNITSKAYA, Aleksandra; LANCIA, JR., David R.; (180 pag.)WO2019/204550; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem