Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 105596-63-2, name is 2-Methoxyisonicotinic acid. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Methoxyisonicotinic acid
Example 4.1 : (S)-2-methoxy-N-methyl-N-(4-(1-methyl-1 H-pyrrole-2-carboxamidoH- phenylbutan-2-yl)isonicotinamide 1-Methyl-1H-pyrrole-2-carboxylic acid ((S)-3-methylamino-4-phenyl-butyl)-amide hydrochloride (100 mg, 0.31 mmol), 2-methoxypyridine-4-carboxylic acid (49 mg, 0.31 mmol), HOBt (71 mg, 0.476 mmol), EDC x HCI (72 mg, 0.37 mmol), and triethylamine (0.108 ml, 0.78 mmol) were dissolved in DCM (5 ml) and stirred at rt for 2 h. The mixture was concentrated, redissolved in EtOAc, washed with sat. NaHC03- and NaCI-soln., dried (Na2S04), filtered and concentrated. The crude product was purified by chromatography (Biotage, DCM to DCM:MeOH 95:5 over 10 min) to yield 84 mg (63 %) of the title compound as white solid. [1 H-NMR (DMSO, 600 MHz) 8.16/7.73 (d, 1 H), 7.93 (t, 1 H), 7.33-7.21, 7.05- 7.01 (2m, 5H), 6.88 (d, 1H), 6.68 (d, 1 H), 6.56/6.11 (d, 1 H), 6.33/5.81 (s, 1H), 6.01-5.98 (m, 1 H), 4.90-4.83/3.58-3.52 (m, 1 H), 3.83/3.76 (s, 3H), 3.81/3.75 (s, 3H), 3.31-3.14 (m, 2H), 3.03-2.90 (m, 1H), 2.96/2.62 (s, 3H), 2.84-2.78 (m, 1 H), 1.89-1.73 (m, 2H); UPLCMS Rt, = 1.09 min; [M+H]+ = 421.3].
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Reference:
Patent; NOVARTIS AG; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; WAGNER, Juergen; ROY, Bernard, Lucien; GERSPACHER, Marc; VON MATT, Anette; BEHNKE, Dirk; WO2011/73316; (2011); A1;,
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