The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H5BrClN
In a Schlenk flask under argon 4-bromo-5-methylthiophene-2-ylboronicacid (3.2 g, 14.14 mmol) was dissolved in THF (25 mL) and degassed.4-bromopyridine hydrochlorid (4.43 g, 22.68 mmol), Pd(dppf)Cl2(740 mg, 0.91 mmol) and aq Na2CO3 solution (20percent, 25 mL) wereadded and the mixture was stirred under reflux overnight at 80 °C.The reaction mixture was extracted three times with DCM, the combined organic phases werewashed with water and brine, dried over MgSO4, filtered and the solvents was removed underreduced pressure. Purification by flash column chromatography (pure cyclohexane + 1percentNEt3) afforded a brownish solid with a yield of 51percent.
With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.
Reference:
Article; Sarter, Christopher; Heimes, Michael; Jaeschke, Andres; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1103 – 1110;,
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