Reference of 1008304-85-5 , The common heterocyclic compound, 1008304-85-5, name is 2-Chloro-6-methoxypyridin-4-amine, molecular formula is C6H7ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Chloro-6-methoxy-pyridin-4-amine (2 g, 12.61 mmol), 3-pyridylboronic acid(1.55 g, 0.01 mol), Pd(amphos)C12 (0.73 g, 0.63 mmol) and K2003 (3.49 g,0.03 mol) were dissolved in MeCN (6 ml) and water (2 ml) and the mixturewas heated in the microwave reactor at 130 00 for 30 mm. The mixture was filtered and the organic layer was evaporated. The resulting residue was dissolved in EtOAc, washed with water, brine, dried over Mg504 and concentrated to give the product as a solid (1 .2 g 47%). MS ES+ m/z 202 [M+H].
The synthetic route of 1008304-85-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SPRINT BIOSCIENCE AB; LINDSTROeM, Johan; FORSBLOM, Rickard; RAHM, Fredrik; VIKLUND, Jenny; (103 pag.)WO2019/38384; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem