Reference of 104508-24-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.104508-24-9, name is 6-(Bromomethyl)picolinonitrile, molecular formula is C7H5BrN2, molecular weight is 197.03, as common compound, the synthetic route is as follows.
Sodium azide (0.280 g, 4.32 mmol) was added to a solution of 6-bromomethyl- pyridine-2-carbonitrile (0.610 g, 2.88 mmol) in DMF (12 ml) and the resulting pale yellow solution was stirred at rt for 16 h. Standard basic workup gave the crude product as a tan solid in quantitative yield (0.501 g).
The chemical industry reduces the impact on the environment during synthesis 104508-24-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem