Adding a certain compound to certain chemical reactions, such as: 147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 147149-98-2, blongs to pyridine-derivatives compound. Product Details of 147149-98-2
2-Trifluoromethyl-4-aminopyridine (1.123 kg, 6.92 mol) was added to a 30 L reactor.2-methyltetrahydrofuran (31.82kg),2,4-Dichloro-6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine (1.857 kg, 6.30 mol),Turn on the agitation,Nitrogen protection,Slowly added N,N-diisopropylethylamine (1.220 kg, 9.44 mol);After heating and refluxing for 30 minutes, the heating was turned off and naturally cooled for 2 hours.After the reaction was completely monitored by HPLC, the mixture was cooled to room temperature, diluted with ethyl acetate (18.00 kg), and poured into a 0.5 mol/L hydrochloric acid solution (15.00 kg) to maintain the internal temperature below 25 C and stirred.Liquid separation,The organic phase was washed twice with 0.25-0.35 mol/L hydrochloric acid solution (10.00 kg).Wash with saturated brine, dry over anhydrous sodium sulfate, and filter.Organic phase concentrationThe title compound was 2.070kg,The yield was 78.2%.
The synthetic route of 147149-98-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Zhao Liwen; Zhang Jin; Chen Cheng; Xu Chenglong; Wang Cheng; (19 pag.)CN110054616; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem