Adding a certain compound to certain chemical reactions, such as: 16135-36-7, Methyl 4-aminonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Methyl 4-aminonicotinate, blongs to pyridine-derivatives compound. Safety of Methyl 4-aminonicotinate
TBTU (1.99 g, 6.19 mmol) was added to a stirred solution of 2′-ethoxy-biphenyl-4-carboxylic acid (1.00 g, 4.13 mmol) and triethylamine (1.73 mL, 12.4 mmol) in dichloromethane (50 mL). After 2 min, 4-amino-nicotinic acid methyl ester (628 mg, 4.13 mmol) was added, and the mixture was heated to reflux for 1 d then allowed to stand at rt for another 2 d. After washing with 1 M aq NaOH (25 mL), water (25 mL) and brine (25 mL the solution was concentrated under reduced pressure. The residue was purified by flash chromatography (silica, 100% DCM to 97:3 DCM/MeOH). Yield 1359 mg (87%). HR-MS (m/z): C22 H20 N2 O4, calcd [M+H]+, 377.1501, found 377.1509.1H NMR (500 MHz, CDCl3) delta 12.21 (s, 1H), 9.24 (s, 1H), 8.93 (d, J = 5.7 Hz, 1H), 8.67 (d, J = 5.4 Hz, 1H), 8.08 (d, J = 8.5 Hz, 2H), 7.76 (d, J = 8.5 Hz, 2H), 7.39 – 7.33 (m, 2H), 7.06 (td, J = 7.5, 0.9 Hz, 1H), 7.01 (d, J = 8.1 Hz, 1H), 4.08 (q, J = 7.0 Hz, 2H), 4.05 (s, 3H), 1.37 (t, J = 7.0 Hz, 3H).
The synthetic route of 16135-36-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bauer, Udo; Giordanetto, Fabrizio; Bauer, Martin; O’Mahony, Gavin; Johansson, Kjell E.; Knecht, Wolfgang; Hartleib-Geschwindner, Judith; Carlsson, Eva Toeppner; Enroth, Cristofer; Bioorganic and Medicinal Chemistry Letters; vol. 22; 5; (2012); p. 1944 – 1948;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem