In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13362-26-0, name is Ethyl 2-aminonicotinate, the common compound, a new synthetic route is introduced below. name: Ethyl 2-aminonicotinate
Example 16 Synthesis of 2-chloro-imidazo[1,2-a]pyridine-8-carboxylic acid (Compound No. 1-135) A mixture of diethyl bromomalonate (26 ml) and ethyl 2-aminonicotinate (13.3 g) was allowed to react at 80-90 C. for 6 hours under nitrogen atmosphere. After completion of the reaction, the mixture was cooled to room temperature, and acetone (100 ml) was added thereto. The precipitated crystals were collected by filtration, affording 3,8-diethoxycarbonyl-2-hydroxy-imidazo[1,2-a]pyridine hydrobromide (9.98 g, yield 34.8%). A mixture of the crystals (6.6 g) in phosphorus oxychloride (30 ml) was reacted at 160 C. for 2 hours in a pressure reaction vessel. After completion of the reaction, excess phosphorus oxychloride was removed under reduced pressure. Ethanol was added to the residue, and the mixture was concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography (eluent: chloroform) to obtain 2-chloro-3,8-diethoxycarbonyl-imidazo-[1,2-a]pyridine (Compound No. 1-133) (2.2 g, yield 40.3%) as crystals of m.p. 105-106 C.
The synthetic route of 13362-26-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US5498774; (1996); A;,
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