Synthetic Route of 65515-28-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65515-28-8, name is Methyl 2,6-dichloronicotinate. A new synthetic method of this compound is introduced below.
A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (8.24 g, 40 mmol), 4-bromophenol (6.92 g,40 mmol), and 50 mL of N, N-dimethylformamide for dissolving them. Triethylamine (7.2 mL, 52mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (672 mg, 6 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40 mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 11.48 g of methyl 6-(4-bromophenoxy)-2-chloronicotinate as a solid, 83.92%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65515-28-8, its application will become more common.
Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
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