Electric Literature of 136590-83-5 , The common heterocyclic compound, 136590-83-5, name is 3,5-Dichloroisonicotinaldehyde, molecular formula is C6H3Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
NaBH4 (0.838 g, 22.2 mmol) was added to a stirred solution of 3,5-dichloro-pyridine-4- carbaldehyde (3.0 g, 17 mmol) in ethanol (40 mL). After stirring for 35 min at room temperature, the reaction mixture was concentrated in vacuo, the residue was redissolved in ethyl acetate (200 mL) and washed with water (50 mL). The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound. MS (m/z): 178.1 [M+H+].
The synthetic route of 136590-83-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JERINI AG; WO2008/116620; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem