Adding a certain compound to certain chemical reactions, such as: 171178-46-4, 5-((tert-Butoxycarbonyl)amino)-2-chloroisonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C11H13ClN2O4, blongs to pyridine-derivatives compound. HPLC of Formula: C11H13ClN2O4
(d) Methyl 5-(tert-butoxycarbonylJ-l-chloroisonicotinate. To a solution of 5-(tert-butoxycarbonyl)-2-chloroisonicotinic acid (1 g, 3.7 mmol) in dry DMF (10 mL), was added NaH (60% suspension in mineral oil, 0.37 g, 9.24 mmol) in small portions with stirring and cooling with an ice-bath. After the addition, the reaction mixture was treated with MeI (0.524 mL, 9.24 mmol) dropwise, and then stirred at room temperature for 1 hour. The reaction mixture was poured into water and stirred at room temperature for 3 hours. The precipitate was filtered and dried in vacuo to afford the title compound as a solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,171178-46-4, 5-((tert-Butoxycarbonyl)amino)-2-chloroisonicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; AMGEN INC.; WO2008/76425; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem