The important role of 5-Bromo-3-fluoropicolinic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 669066-91-5, 5-Bromo-3-fluoropicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference of 669066-91-5 ,Some common heterocyclic compound, 669066-91-5, molecular formula is C6H3BrFNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 5-bromo-3-fluoropyridine-2-carboxylic acid (2.7 g, 12.27 mmol, 1 equiv.) and H2S04 (5 mL) in MeOH (10 mL) was stirred at 85 C for 1 hour. The mixture was basified to pH 7 with saturated NaHCO3. The resulting mixture was extracted with EA (3x) and evaporated to afford the title compound (2.3 g) as off white solid. ESI-MS m/z= 233.90[M+Hjt

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 669066-91-5, 5-Bromo-3-fluoropicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; OR, Yat, Sun; BLAISDELL, Thomas, P.; SHOOK, Brian, C.; KIM, In, Jong; (98 pag.)WO2018/226801; (2018); A1;,
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