Electric Literature of 61338-13-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 61338-13-4, name is 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
Stirring blade,In a 1 L three-necked flask equipped with a thermometer, 60 g (201.8 mmol) of the pyridine carboxylic acid compound was suspended in 270 mL of tetrahydrofuran,It was cooled to 10 C.Under nitrogen flow70% sodium bis (2-methoxyethoxy) aluminum hydrideOf a toluene solution240 g (706.2 mmol) was added dropwise,The reaction was carried out at 40 C. for 5 hours.After completion of the reaction,The reaction solution was cooled to 10 C.,The reaction solution was added to 275 mL of a 35% by mass Rochelle salt aqueous solution cooled to 10 C. with stirring for 5 minutes.The temperature of the mixed solution at this time was 15 C.In addition, precipitation of aluminum hydroxide was not confirmed.Thereafter, the mixture was stirred for 10 minutes, and an organic layer and an aqueous layer were separated.The organic layer was concentrated under reduced pressure to obtain a pyridine methanol compound as a residue.240 mL of diethyl ether was added to the residue, and the mixture was stirred at room temperature for 30 minutes to obtain a crystallized pyridine methanol compound.After filtering the crystals,Dried under reduced pressure at 40 C. for 5 hours,Pyridine methanol compound (51 g).(Yield 89%, purity 99.3%, excess reductant amount 0.2%).
According to the analysis of related databases, 61338-13-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TOKUYAMA CORPORATION; KASAI, SOKO; MIYAOKU, TAKAYUKI; (10 pag.)JP2017/154976; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem