Application of 932-35-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 932-35-4, name is 3-Hydroxypicolinonitrile, molecular formula is C6H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation XV 2-Cyano-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside A solution of 1.7 g (14.17 mM) of 2-cyano-3-pyridinol in 80 ml of acetonitrile is prepared and 4.3 g (18.3 mM) of silver oxide and 3 g of 13* molecular sieve are added with the exclusion of light. The mixture is stirred at 50 C. for 10 min, 6.5 g (18.3 mM) of 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranosyl bromide are then added and the reaction mixture is maintained at 50 C. for 18 hours with stirring. The mixture is subsequently cooled to ambient temperature and filtered through a filtration aid. The filtrate is diluted with ethyl acetate, washed with water, an N sodium hydroxide solution and then water to neutral pH and finally dried over magnesium sulfate and concentrated under reduced pressure. The residual oil is crystallized by addition of ethyl ether. 0.89 g of the expected product is obtained in the form of beige crystals (yield=16%). 1H NMR (300 MHz; CDCl3) delta: 8.43 (m, 1H), 7.53 (m, 2H), 5.49 (t, 1H), 5.30 (d, 1H), 5.19 (m, 2H), 3.18 (m, 1H), 2.76 (m, 1H), 2.10 (m, 9H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 932-35-4, 3-Hydroxypicolinonitrile.
Reference:
Patent; Laboratoires Fournier S.A.; US2009/182013; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem