With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71469-93-7, name is Methyl 4-aminopyridine-2-carboxylate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.Product Details of 71469-93-7
Example (Ik-130) N-[2-(2,2-Difluorocycloprop-1-ylcarbamoyl)pyrid-4-yl]-1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide The reaction with methyl 4-aminopyridine-2-carboxylate (cf. WO 2001/074788) takes place analogously to the reaction procedure in Example (Ik-127) using: 486 mg (3.19 mmol) of methyl 4-aminopyridine-2-carboxylate in 26.8 ml of dichloromethane, 1056 mg (3.19 mmol) of 1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride, 428 mg of silver(I) cyanide in 26.8 ml of acetonitrile. The remaining residue is purified by means of column chromatography on silica gel using the eluent mixture cyclohexane:acetone (gradient). This gives 984 mg of methyl 4-({[1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)pyridine-2-carboxylate (69%). 1H-NMR (400 MHz, d6-DMSO): delta=8.67 (d, 1H), 8.31 (s, 1H), 7.80 (d, 1H), 4.03 (s, 3H), 3.90 (s, 3H) ppm. HPLC-MSa): log P=3.01; mass (m/z)=447 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,71469-93-7, Methyl 4-aminopyridine-2-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Bayer CropScience AG; US2011/301181; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem