Reference of 3167-49-5 , The common heterocyclic compound, 3167-49-5, name is 6-Aminonicotinic acid, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Reference Example 190 6-Amino-5-bromopyridine-3-carboxylic acid To a stirred solution of 6-aminonicotinic acid (13.8 g, 0.1 mole) in glacial acetic acid (100 ml), bromine (16 g, 5 ml, 0.1 mole) in acetic acid (20 ml) is added slowly. The reaction mixture is stirred for 8 hours at room temperature and the acetic acid is removed under reduced pressure. The yellow solid residue is dissolved in water and carefully neutralized with 30% NH4 OH. The separated solid is filtered and washed with water to give 18 g of solid; mass spectrum: 218 (M+).
The synthetic route of 3167-49-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; American Cyanamid Company; US5719278; (1998); A;,
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