Analyzing the synthesis route of 16830-24-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16830-24-3, Methyl 2-methylisonicotinate, other downstream synthetic routes, hurry up and to see.

Reference of 16830-24-3 ,Some common heterocyclic compound, 16830-24-3, molecular formula is C8H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of (NH4)25208 in water was added to a solution of methyl 2-methylpyridine-4-carboxylatein methanol at reflux. The resulting reaction mixture was then stirred at reflux. Aqueous work up andrecrystallization from DCM afforded the title compound as white solid. ?H-NMR (300 MHz, CDC13): oe7.60 (s, 2 H), 4.78 (s, 2 H), 3.93 (s, 3 H), 3.81 (s (br), 1 H), 2.61 (s, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16830-24-3, Methyl 2-methylisonicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EPITHERAPEUTICS APS; BOESEN, Thomas; LABELLE, Marc; YANG, Ying; SARASWAT, Neerja; DUDEKULA, Dastagiri; COOK, Cyril John; VAKITI, Ramkrishna Reddy; ZHANG, Rui; ULLAH, Farman; (316 pag.)WO2016/33169; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem