Adding a certain compound to certain chemical reactions, such as: 113237-20-0, 2,6-Dichloro-5-fluoronicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 113237-20-0, blongs to pyridine-derivatives compound. Recommanded Product: 2,6-Dichloro-5-fluoronicotinamide
To a stirred solution of 2,6dichloro-5-fiuoro-pyridine-3-carboxamide (95 g, 0.45 mol) in MeOH (45 mL) and AcOH (450 mL) was added Zn powder (41.92 g, 0645 mol). The resulting reaction mixture was heated at 85 C for 15 h. After TLC (petroleum ether: EtOAc1:1) showed the completion of the reaction, the reaction mixture was diluted with saturated aqueous NaHCO3 solution and extracted with EtOAc. The organic layer was driedover anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue, after being washed with hexane several times gave the title compound (70 g, 88% yield) as a solid.MS: 173.0 [M-H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113237-20-0, its application will become more common.
Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; TAN, Xuefei; ZBINDEN, Katrin Groebke; KUHN, Bernd; WANG, Lisha; LIU, Yongfu; WU, Jun; SHEN, Hong; SHI, Tianlai; (174 pag.)WO2017/133664; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem