Application of 19798-77-7 ,Some common heterocyclic compound, 19798-77-7, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In 100mL three-necked flask was added 3-chloro-4-aminopyridine 1.3g (10. Ommo 1),Dichloromethane 30ml,Ice water bath cooled to 0 ~ 5 C,Dropping 1)Step prepared phenazine-1-carboxylic acid chloride(11.2mm0l) in dichloromethane, after the addition was completed, incubated 0 ~ 5 C reaction lh, point plate monitoring, the reaction was complete. The solvent was removed by adding 50 ml of methylene chloride and the organic layer was sufficiently washed with a 5% aqueous hydrochloric acid solution. The organic layer was separated and the organic layer was washed with a 5% aqueous sodium hydroxide solution. The organic layer was separated and dried over anhydrous sodium sulfate 1 hour, suction filtration, the filtrate was stripped to obtain the amide 3.15g. Yield 94%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19798-77-7, 4-Amino-3-chloropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Yangtze University; Wu Qinglai; Qin Chuan; Li Junkai; (36 pag.)CN107459490; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem