Adding a certain compound to certain chemical reactions, such as: 17997-47-6, 2-(Tributylstannyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(Tributylstannyl)pyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 2-(Tributylstannyl)pyridine
A mixture of (S)-2-( 1 -(2-chloro-7-fluoroquinolin-3 -yl)ethyl)isoindoline- 1,3 -dione (85.6 g, 241 mmol), Pd(PPh3)4 (14 g, 12.1 mmol, 0.O5eq) and 2-(tributylstannyl)pyridine (107 g, 289 mmol, 1.2 eq) in dioxane (3.0 L) was heated to 90 C under N2 overnight, then heated to 101 C for additional 2 days. The reaction mixture was cooled to room temperature, decanted and the final 200 mL solution was filtered. The combined solvents were concentrated to 300 mL and filtered to give a tan solid, which was washed with EtOAc/hexane (1/1) and dried (82.1 g). The mother liquor was concentrated to 100 mL and treated with EtOAc/hexane, 1/1 (200 mL) to give additional 2.2 g tan solid, overall 84.3 g.
The synthetic route of 17997-47-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; KELLY, Ron, C.; WORTMAN, Sarah; WO2015/171725; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem