Electric Literature of 62068-78-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62068-78-4, name is 2,6-Dichloronicotinamide, molecular formula is C6H4Cl2N2O, molecular weight is 191.02, as common compound, the synthetic route is as follows.
To a stuffed solution of 2,6-dichloro-nicotinamide (500.00 mg; 2.62 mmol; 1.00 eq.) in DMF (5.00 ml; 10.00 V) was added 3-(4-hydroxy-phenoxy)-benzonitrile (670.16 mg; 3.14 mmol; 1.20 eq.) and cesium carbonate (1722.97 mg; 5.24 mmol; 2.00 eq.) at RT. The resulting reaction mixture was stirred for 5h. The reaction completion was confirmed by TLC. After completion of the reaction, the reaction mixture was quenched by the addition of water (20 mL). The solid was collected by filtration and dried under vacuum. The solid was further triturated with acetonitrile (25 mL) and filtered and dried under vacuum to afford 6-chloro-2-[4-(3-cyano- phenoxy)-phenoxy]-nicotinamide (800.00 mg; 83.6 %; off white solid). HPLC: 98.06% purity. MS: m/z = 364.0 [M+H].
The chemical industry reduces the impact on the environment during synthesis 62068-78-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK PATENT GMBH; QIU, Hui; CALDWELL, Richard D.; NEAGU, Constantin; MOCHALKIN, Igor; LIU-BUJALSKI, Lesley; JONES, Reinaldo; TATE, Devon; JOHNSON, Theresa L.; GARDBERG, Anna; WO2015/61247; (2015); A2;,
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