Synthetic Route of 1211516-25-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1211516-25-4, name is 6-Bromo-5-methylpicolinic acid. A new synthetic method of this compound is introduced below.
3-Chlorophenylboronic acid (CAN 63503-60-6, 0.61 g, 3.9 mmol), 1 , l’-bis(diphenyl- phosphino)ferrocene-palladium(II)dichloride methylene chloride complex (CAN 95464- 05-4, 53 mg, 0.065 mmol) and potassium carbonate (CAN 584-08-7, 0.54 g, 3.9 mmol) was added to a solution of 6-bromo-5-methyl-pyridine-2-carboxylic acid (0.7 g, 3.2 mmol) in water ( 30 mL). The mixture was stirred at 100°C overnight. The reaction mixture was adjusted to pH = 3 and the mixture was extracted with ethyl acetate (3 x 20 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated in vacuo to give product (0.55 g, 56.9percent); MS (EI): m/e 248.1 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1211516-25-4, 6-Bromo-5-methylpicolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BISSANTZ, Caterina; GRETHER, Uwe; HEBEISEN, Paul; KIMBARA, Atsushi; LIU, Qingping; NETTEKOVEN, Matthias; PRUNOTTO, Marco; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHULZ-GASCH, Tanja; ULLMER, Christoph; WANG, Zhiwei; YANG, Wulun; WO2012/168350; (2012); A1;,
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