The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C11H15NO3
2.09 g (3.5 mmol) of 5-hydroxymethyl2,2-dimethyl-4H-[1 ,3]dioxino[4,5-c]picoline was dissolved in 50 ml_ EtOAc then cooled to 0 C. 1 ml_ triethylamine was added followed by 1.15 g pf methane sulfonyl chloride. The mixture was stirred for 30 min. A solution of 1.12 g 4-fluorophenol in 5 ml_ DMF was cooled to 0 C and 1.12 g potassium tert-butanoate was added to form a phenol salt. This solution was added to the other at which point a gel formed. This was stirred and allowed to warm to room temperature for 1 h. The solution was then quenched by addition of water and adjusting the pH to 4 with acetic acid. The organic phase was evaporated. The residue was then adsorbed on silica gel then washed over a pad of silica gel with DCM. The DCM was evaporated to yield 2.4 g of a clear oil which spontaneously crystallized.
With the rapid development of chemical substances, we look forward to future research findings about 1136-52-3.
Reference:
Patent; MONTREAL HEART INSTITUTE; POIRIER, Steve; STRANIX, Brent Richard; MAYER, Gaetan; (82 pag.)WO2019/84681; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem