Related Products of 36052-24-1 , The common heterocyclic compound, 36052-24-1, name is Methyl 6-aminonicotinate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 15 (1.0 equiv., 3.94 mmol, 0.600 g) was added portion wise to a suspension OfLiAlH4 (3.00 equiv., 11.83 mmol, 0.449 g) in dry THF (17 ml) at 00C. The reaction mixture was stirred at room temperature overnight. Excess LiAlH4 was destroyed by addition of methanol (while cooling on ice), the reaction mixture was filtered over Celite and the filtrate concentrated under reduced pressure. The crude product was purified by column chromatography (dichloromethane / methanol 75:25) to give 6-amino-3-pyridinemethanol (16) (0.330 g, yield = 67%) as a white solid. 1H NMR (delta, CD3OD): 4.43 (2H, s), 6.58 (IH, d, J = 8.5 Hz), 7.48 (IH, dd, J = 8.5, ~ 2 Hz) 7.86 (IH, d, J ~ 2 Hz)
The synthetic route of 36052-24-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tibotec Pharmaceuticals Ltd.; WO2007/113290; (2007); A1;,
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