Adding a certain compound to certain chemical reactions, such as: 5346-38-3, Pyridine-2-carbothioamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5346-38-3, blongs to pyridine-derivatives compound. Computed Properties of C6H6N2S
Pyridinecarbothioamides 26-28 (1 eq.) and dichloroacetone(1 eq.) were dissolved in toluene (1 M) and heated to reflux (110 C).After completion of the reaction, the mixture was cooled to roomtemperature and extracted with EtOAc (3 times) and the organiclayer was washed (brine), dried (MgSO4), filtered and concentratedin vacuo. The product was purified by column chromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5346-38-3, its application will become more common.
Reference:
Article; Louvel, Julien; Guo, Dong; Soethoudt, Marjolein; Mocking, Tamara A.M.; Lenselink, Eelke B.; Mulder-Krieger, Thea; Heitman, Laura H.; Ijzerman, Adriaan P.; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 681 – 691;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem