As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Picolinaldehyde
2-Pyridylbenzaldehyde (10.7 g, 0.1 mol), malonic acid (25.5 g, 0.25 mol) was added to a 100 ml round bottom flask.30 ml of pyridine was added as a solvent, magnetically stirred, and after all of it was dissolved, 1.6 g of piperidine was injected into the system.The oil bath was heated to 65 C and reacted for 3 h.The reaction was followed by thin layer chromatography, and after the reaction was completed, the reaction solution was cooled to 0-5 C.Pour into a mixture of ice and water containing concentrated hydrochloric acid (12 mol / l, 50 ml), a large amount of white solids precipitated, suction filtration,The desired 2-pyridine acrylic acid was obtained in a molar yield of 78%.
With the rapid development of chemical substances, we look forward to future research findings about 1121-60-4.
Reference:
Patent; Danyang Ning David Fang To Detect Co., Ltd.; Wei Qian; (4 pag.)CN109748851; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem