Statistics shows that 59718-84-2 is playing an increasingly important role. we look forward to future research findings about Methyl 3-methylpicolinate.
Application of 59718-84-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59718-84-2, name is Methyl 3-methylpicolinate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.
5 g quantity of methyl 3- [2- (3-benzyloxy-4-methoxy phenyl) oxazol-4-yl] propionate obtained in Reference Example 48 and 3.2 g of methyl 3-methylpicolinate were dissolved in 150 ml of dimethoxyethane. While stirring the solution with ice cooling 1.2 g of sodium hydride was added thereto and further stirred. The reaction mixture was heated and refluxed for 4 hours. At the completion of the reaction, a saturated aqueous ammonium chloride solution was added to the mixture while stirring with ice cooling, and the mixture was further stirred. After stirring the reaction mixture for 30 minutes, water was added thereto and ethyl acetate extraction was performed. The organic layer was washed twice with water, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n- hexane: ethyl acetate = 2:1), thereby yielding 5.5 g of colorless oily substance methyl 2- [2- (3-benzyloxy-4-methoxyphenyl) oxazol-4- ylmethyl] -3- (3-methylpyridin-2-yl) -3-oxopropionate. 1H-NMR (CDCl3) delta: 8.49 (IH, dd, J = 4.8, 1.2 Hz), 7.59-7.28 (1OH, m), 6.91 (IH, d, J = 9.0 Hz), 5.23-5.16 (3H, m) , 3.91 (3H, s) , 3.65 (3H, s), 3.37-3.18 (2H,m,) 2.59 (3H, s)
Statistics shows that 59718-84-2 is playing an increasingly important role. we look forward to future research findings about Methyl 3-methylpicolinate.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; WO2007/58338; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem