Adding a certain compound to certain chemical reactions, such as: 13535-01-8, 5-Bromopyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13535-01-8, blongs to pyridine-derivatives compound. Recommanded Product: 13535-01-8
To a solution of 5-bromopyridin-3-amine (4.75 g, 27.45 minol) in dioxane (45 mL) was added cyclopropylboronic acid (4.75 g, 55.30 minol), C52CO3(28 g, 85.67 minol), tetrakis(triphenylphosphane) palladium(1.66 g, 1.44 minol) and water (5 mL) at room temperature. The resultingminxture was then stirred for 15 h at 100 C. After cooling to room temperature, the reaction mxiture was diluted with water (200 mL). The resultingminxture was extracted with ethyl acetate (500 mL x 3). The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0% to 100% gradient) to yield 5-cyclopropylpyridin-3-amine as light brown oil (2.08 g, 56%). MS: m/z = 135.0 [M+Hj .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13535-01-8, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian A.; BRUGGER, Nadia; (546 pag.)WO2017/106607; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem