Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112575-13-0, name is 6-Bromo-N,N-dimethylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 6-Bromo-N,N-dimethylpyridin-2-amine
b (3R,4S)-4-[4-(6-Dimethylaminopyridin-2-yl)phenoxy]-1-pyridin-3-ylpentan-3-ol Prepared according to the method described in Example 15g) from toluene (4 ml), 2M aqueous sodium carbonate (0.5 ml), (1S,2R)-4-[2-(tert-butyldimethylsilanyloxy)-1-methyl-4-pyridin-3-yl-butoxy]benzeneboronic acid (0.200 g, Example 15f)), ethanol (1 ml), 6-bromo-2-N,N-dimethylaminopyridine (0.201 g, Example 18a)) and tetrakis(triphenylphosphine)palladium(0) (0.020 g) with heating at 120 C. for 4 hours. The product was purified by normal-phase HPLC eluding with a gradient of 0-25% ethanol in dichloromethane to give the title compound as an oil (0.091 g). MS (APCI) 378 (M+H)+ 1 H NMR (DMSO) 8.43(1H, s); 8.38(1H, d); 7.95(2H, d); 7.63(1H, d); 7.52(1H, t); 7.32-7.27(1H, m); 7.04(1H, d); 6.95(2H, d); 6.52(1H, d); 4.98(1H, d); 4.37-4.29(1H, m); 3.60-3.51(1H, m); 3.08 (6H, s); 2.84-2.76(1H, m); 2.69-2.61(1H, m); 1.91-1.81(1H, m); 1.69-1.58(1H, m); 1.24(3H, d).
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Reference:
Patent; AstraZeneca UK Limited; US6143751; (2000); A;,
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