Application of 19524-06-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.
CuI (95 mg, 0.50 mmol), (Ph3P)2PdCl2 3(174 mg, 0.25 mmol), Na ascorbate (98 mg, 0.50 mmol) and 4-bromopyridinehydrochloride 22 (970 mg, 5.0 mmol) wereplaced in a flask, which was degassed and filled with Ar. Pri2NH (10 mL) andTHF (10 mL) were added. The mixture was stirred at 40°C for 30 min. Me3SiC?CH (532 mg, 5.0 mmol) was added and themixture was stirred at 40°C for 10 h. Evaporation and chromatography (petroleumether / EtOAc 5:1 ? 3:1) gave 20l (767mg, 89percent) as a pale buff oil (lit.7 yellow liquid); 1H NMR(CDCl3) d 0.27 (9 H, s, SiMe3), 7.29 (2 H, d, J = 4.4 Hz, 3,5-H2) 8.55 (2 H, d, J = 4.4 Hz, 2,6-H2); 13C NMR (CDCl3)d -0.002 (SiMe3),100.24 (ethyne 2-C), 102.31 (ethyne 1-C), 126.16 (3,5-C2), 131.52(4-C), 150.03 (2,6-C2).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19524-06-2, 4-Bromopyridine hydrochloride.
Reference:
Article; Kumpan, Katerina; Nathubhai, Amit; Zhang, Chenlu; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Haikarainen, Teemu; Lehtioe, Lari; Threadgill, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3013 – 3032;,
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