The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54221-96-4, name is 6-Methoxypicolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H7NO2
General procedure: The mixture of benzaldehyde (3a) (1 mL, 0.010 mol), 2 (2.45 g,0.010 mol) and triethyl phosphite (4) (3.4 mL, 0.020 mol) was placed in a round bottomed flask. To this mixture, 37percent nano-BF3*SiO2 (0.30g) was added and the mixture was irradiated in the ultrasonicator at ambient temperature for about 10 minutes. The progress of the reaction was monitored by TLC (EtOAc/nhexane7:3). After completion of the reaction as checked byTLC, the reaction mixture was cooled to room temperature. CH2Cl2 (15 mL) was added to the reaction content and stirred for 10 min. The catalyst nano-BF3*SiO2 was separated by filtrationas residue, washed with CH2Cl2 (2 × 10 mL) and the residue was dried under vacuum at 100°C to be utilized in further studies. The combined organic layer was washed with water (15 mL), dried over anhydrous Na2SO4 and concentrated under vacuum at 50°C to obtain crude 5a. Pure 5a was obtained by column chromatography (EtOAc/n-hexane 7:3). The same procedure was used for the preparation of the remaining compounds 5b-k.
With the rapid development of chemical substances, we look forward to future research findings about 54221-96-4.
Reference:
Article; Ravikumar; Mohan; Subramanyam, Ch.; Rao, K. Prasada; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 193; 6; (2018); p. 400 – 407;,
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