Reference of 1187236-18-5, Adding some certain compound to certain chemical reactions, such as: 1187236-18-5, name is Ethyl 7-bromoimidazo[1,2-a]pyridine-2-carboxylate,molecular formula is C10H9BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1187236-18-5.
A mixture of 258-2 (300 mg, 1.12 mmol), B (356 mg, 1.23 mmol), Cul (21 mg, 0.11 mmol), K3PO4 (473 mg, 2.23 mmol), and picolinic acid (28 mg, 0.22 mmol) in DMSO (6 ml) is sparged with N2 for 5 min, and heated at 90 C overnight. The reaction mixture is cooled to ambient temperature, diluted with EtOAc and water, and filtered. The filtrate is washed with water and brine. The organic layer is dried, concentrated, and purified Si02 (0-6%, MeOH in DCM) to give 258-3
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1187236-18-5, Ethyl 7-bromoimidazo[1,2-a]pyridine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ABEYWARDANE, Asitha; BRUNETTE, Steven Richard; BURKE, Michael Jason; KIRRANE, Thomas Martin, Jr.; MAN, Chuk Chui; MARSHALL, Daniel Richard; PADYANA, Anil Kumar; RAZAVI, Hossein; SIBLEY, Robert; SMITH KEENAN, Lana Louise; SNOW, Roger John; SORCEK, Ronald John; TAKAHASHI, Hidenori; TAYLOR, Steven John; TURNER, Michael Robert; YOUNG, Erick Richard Roush; ZHANG, Qiang; ZHANG, Yunlong; ZINDELL, Renee M.; WO2014/14874; (2014); A1;,
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