Introduction of a new synthetic route about 2-Chloronicotinamide

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10366-35-5, 2-Chloronicotinamide, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 10366-35-5, 2-Chloronicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H5ClN2O, blongs to pyridine-derivatives compound. HPLC of Formula: C6H5ClN2O

General procedure: To a solution of the corresponding amide (2 mmol) in THF (10 mL) was added chlorocarbonylsulfenyl chloride (350 muL, 4 mmol). The mixture was stirred at ambient temperature for 16 h. The solvent was removed in vacuo and the crude products were puried by silica-gel column chromatography using ethyl acetate/hexane as eluent solvent system.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10366-35-5, 2-Chloronicotinamide, and friends who are interested can also refer to it.

Reference:
Article; Yang, Jianzhong; Pi, Weiyi; Xiong, Li; Ang, Wei; Yang, Tao; He, Jun; Liu, Yuanyuan; Chang, Ying; Ye, Weiwei; Wang, Zhenling; Luo, Youfu; Wei, Yuquan; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1424 – 1427;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem