Application of 80194-69-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 80194-69-0, name is 5-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of (1S, 4S)-2-{(15)-1-[4-(allyloxy)-2,3-dimethylphenyl]ethyl}-2,5-diazabicyclo-[2.2.1]heptane (7.3 g, 25.5 mmol), 5-(trifluoromethyl)pyridine-2-carboxylic acid (4.97 g, 26.0 mmol), BOP (16.9 g, 38.3 mmol) and NEt3 (8.89 mL, 63.8 mmol) in N,N-dimethylacetamide (50 mL) is heated at 40 C. under N2 overnight. The reaction mixture is cooled to room temperature, diluted with 1N NaOH (100 mL), and extracted with EtOAc. The organic layer is isolated, washed with 1N NaOH, water and brine, dried over Na2SO4, and concentrated under reduced pressure. The residue is purified by silica gel chromatography with EtOAc as the eluent to afford the title compound as a brown oil. 1HNMR (400 MHz, CDCl3) delta: 8.86 (s, 0.67H), 8.83 (s, 0.33H), 8.02-8.13 (m, 2H), 7.28 (m, 1H), 6.72 (m, 1H), 6.07 (m, 1H), 5.43 (m, 1H), 5.26 (m, 1H), 4.97 (s, 1H), 4.49-4.53 (m, 2H), 3.72-4.00 (m, 2H), 3.52 (m, 1H), 3.35 (m, 1H), 3.22 (m, 1H), 2.83 (d, 0.67H), 2.78 (d, 0.33H), 2.33 (s, 2H), 2.25 (s, 1H), 2.21 (s, 2H), 2.19 (s, 1H), 1.95 (m, 1H), 1.72 (m, 1H), 1.25-1.31 (m, 31). LC-MS m/z (M+H): 460.
According to the analysis of related databases, 80194-69-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hutchinson, Alan J.; Chenard, Bertrand L.; Li, Guiying; Ghosh, Manuka; Tarrant, James G.; Yoon, Taeyoung; Luke, George P.; Lee, Kyungae; O’Donnell, Mary-Margaret E.; Pringle, Wallace C.; Peterson, John M.; Hodgetts, Kevin J.; Steenstra, Cheryl K.; Doller, Dario; US2006/9456; (2006); A1;,
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