Application of 15854-87-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15854-87-2, name is 4-Iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.
The intermediates and final products were obtained via establishedcross-coupling reactions [5,15,17]. Briefly, 4-trimethylsililyethynylpyridine was obtained by reacting an equimolarquantity of 4-iodopyridine (2.0 mmol) with trimethylsilylethyne(TMSE, 2.0 mmol) in THF/iPrNH2 using Pd(II)/Cu(I) catalysts(Scheme 1). The crude product obtained was purified by silicacolumn chromatography using hexane/dichloromethane eluantsystems. This was followed by a protodesilylation reaction underbasic condition (aq. KOH in MeOH/THF) and the 4-ethynylpyridinewas separated by silica column chromatography using puredichloromethane as eluant. In the next phase of the reaction,respective aryl halides (2.0 mmol) and 4-ethynylpyridine (2.0mmol) were coupled via a Sonogashira cross-coupling reaction.Final products were purified using an alumina column and obtainedas tan to light brown solid in quantitative yields.
According to the analysis of related databases, 15854-87-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Haque, Ashanul; Al Balushi, Rayya A.; Al-Busaidi, Idris Juma; Ilmi, Rashid; Al Rasbi, Nawal; Jayapal, Maharaja; Khan, Muhammad S.; Raithby, Paul R.; Journal of Organometallic Chemistry; vol. 892; (2019); p. 75 – 82;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem