Adding a certain compound to certain chemical reactions, such as: 144100-07-2, 2-Bromo-6-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Bromo-6-fluoropyridine, blongs to pyridine-derivatives compound. Quality Control of 2-Bromo-6-fluoropyridine
A solution of 2-bromo-6-fluoropyridine (2.4 g, 13.64 mmol), o-tolylboronic acid (2.039 g, 15.00 mmol) and Tetrakis (0.158 g, 0.136 mmol) in Dioxane was degassed by nitrogen bubble for 10 min. A solution of Phosphoric acid, potassium salt (8.68 g, 40.9 mmol) in H20 (2ml) was then added and the solution heated to reflux for 18 h. The crude material was purified via silica gel chromatography (90g SiOi column, hexane:EtOAc 100:0 -> 90: 10) to afford 2-fluoro-6-(o-tolyl)pyridine, 2.41 g (94percent). NuMuRhonu (400 MHz, CDCb) delta 7.87 (q, J=8.2 Hz, 1H), 7.46 – 7.41 (m, 1H), 7.37 – 7.26 (m, 4H), 6.92 (dd, J=8.2, 2.9 Hz, 1H), 2.43 (s, 3H).
The synthetic route of 144100-07-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BOWSHER, Michael S.; DESKUS, Jeffrey; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (220 pag.)WO2018/127801; (2018); A1;,
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