With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.93-60-7, name is Methyl nicotinate, molecular formula is C7H7NO2, molecular weight is 137.136, as common compound, the synthetic route is as follows.Application In Synthesis of Methyl nicotinate
A 10 l Buechi stirred autoclave with gas inlet tube, stirrer, internal thermometer and pressure equalizer was initially charged with 1.72 kg of methyl nicotinate (12.5 mol). 3.68 kg of diethylamine (50 mol) and 100 g of potassium tert-butoxide as a catalyst were slowly added thereto, and the mixture was homogenized while stirring.The reaction mixture thus obtained was pumped through the reaction tube continuously at 4 l/h at a working pressure of 30 bar and exposed to a microwave power of 2.8 kW, 91% of which was absorbed by the reaction mixture. The residence time of the reaction mixture in the irradiation zone was approx. 42 seconds. At the end of the reaction tube, the reaction mixture had a temperature of 285 C. Immediately after leaving the reactor, the reaction mixture was cooled to room temperature with a jacketed coil heat exchanger.A conversion of 85% of theory was attained. The reaction product was pale yellowish in color; the iron content was <5 ppm. After distillative removal of the methanol formed and of the excess or unconverted reactants, 1.85 kg of N,N-diethylnicotinamide with a purity of 98% were obtained by means of vacuum distillation.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,93-60-7, Methyl nicotinate, and friends who are interested can also refer to it.
Reference:
Patent; CLARIANT FINANCE (BVI) LIMITED; US2012/95238; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem