Extracurricular laboratory: Synthetic route of N,N-Dimethylnicotinamide

Statistics shows that 6972-69-6 is playing an increasingly important role. we look forward to future research findings about N,N-Dimethylnicotinamide.

Related Products of 6972-69-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6972-69-6, name is N,N-Dimethylnicotinamide, molecular formula is C8H10N2O, molecular weight is 150.1778, as common compound, the synthetic route is as follows.

Step 2:[336] (0.05 g, 0.072 mmol, 1.0 eq) sodium iodide (0.038 g, 0.21 mmol, 3.0 eq) and nicotinamide [322] (0.011 g, 0.072 mmol, 1.0 eq) were added in ACN (3 ml). The reaction mixture was stirred at RT for 16 h in dark. Reaction progress was monitored by TLC. Solvent was removed under vacuum to get a crude product. The crude product obtained was triturated with diethyl ether (2 x 10 ml) to get the desired product [337], as black solid (0.044 g, 75%).

Statistics shows that 6972-69-6 is playing an increasingly important role. we look forward to future research findings about N,N-Dimethylnicotinamide.

Reference:
Patent; SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; WO2012/137225; (2012); A1;,
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