Electric Literature of 86129-63-7, Adding some certain compound to certain chemical reactions, such as: 86129-63-7, name is Ethyl 2,4-dichloro-6-methyl-3-pyridinecarboxylate,molecular formula is C9H9Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86129-63-7.
To a solution of intermediate 33 (9.73 g, 1.5 eq) in anh. DMF (150 mL), at r. t. , under N2, was added NaH 60%/OIL (1.7 g, 1 eq) and the reaction mixture was stirred at r. t. for 20 min. A solution of ethyl 2, 4-dichloro-6-methyl-3-pyridinecarboxylate (10 g, 42.9 MMOL) was then added dropwise and the reaction mixture was stirred at 80oC for 4 hr. It was then cooled down to r. t. and quenched with ice water. The addition of EtOAc caused a precipitate to form. The white solid was collected by filtration, washed with water and dried in vacuo (5.2 g). The filtrate was transferred into a separatory funnel and the aqueous layer was extracted with EtOAc (2X100 mL). The combined organic layers were washed with sat. aq. NACI, dried over anh. NA2SO4, the solids were filtered and the solvent evaporated. The crude product was treated with EtOAc and left at r. t. overnight. The precipitate was filtrated, dried in vacuo and combined with the previous batch to give the title compound as a white solid (7.2 g, 48%). NMR (‘H, DMSO-D6) : 5 8.53 (d, 1H), 7.77 (s, 1H), 7.18 (bs, 1H), 6.89 (d, 1H), 4.32 (q, 2H), 3.75 (t, 2H), 3.42 (t, 2H), 3.31 (s, 3H), 1.26 (t, 3H). MS (M/Z) : 350 [MH] +.
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Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; WO2004/94419; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem