As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1702-17-6, name is 3,6-Dichloropicolinic acid, molecular formula is C6H3Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 3,6-Dichloropicolinic acid
To a solution of compound 1(100 g, 520.8 mmol) in EtOH (400 mL) was added drop- wise SOd2 (155 g, 1.3 mol) at 0 C Then the mixture was stirred at 90 C for 2 h. TLC(PE:EA=3:1, Rf =0.5) showed the reaction was completed. The solvent was evaporated underreduced pressure. The mixture was add saturated NaHCO3 adjusted PH=7 and extracted with EA (200 ml*3). The combined organic layer was dried with Na2SO4, filtered and concentrated to give compound (120 g, 100%) as yellow oil. LC-MS (M+H) =220.
With the rapid development of chemical substances, we look forward to future research findings about 1702-17-6.
Reference:
Patent; BEIGENE, LTD.; WANG, Hexiang; ZHANG, Guoliang; GUO, Yunhang; REN, Bo; WANG, Zhiwei; ZHOU, Changyou; (219 pag.)WO2016/161960; (2016); A1;,
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