Application of 14237-71-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14237-71-9, name is 2-Chloro-4,6-dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: In a 100 mL round bottom flask, compound 2a (0.7 g, 4.0 mmol),P-methylaniline (1.3 g, 12.0 mmol) and DMSO (15 mL) were stirred and heated in an oil bath at 120 under N2 protection(The progress of the reaction was monitored by TLC, developing solvent: ethyl acetate: petroleum petroleum = 1: 10). After the reaction is completed, cool to room temperature.Extract with saturated NaHCO3 solution (3 × 30 mL) and DCM solution (5 × 30 mL), combine the organic phases,Wash with saturated NaCl solution 3 ~ 4 times, dry with anhydrous Na2SO4, and concentrate under reduced pressure.Purification by silica gel column chromatography (eluent: V ethyl acetate: V petroleum ether = 1: 45) to obtain compound 3aa as a white powder. Yield: 39%.
According to the analysis of related databases, 14237-71-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guilin Medical University; Huang Wanyun; Zhang Xiaoting; Zheng Bin; Lv Liang; Wang Shuqin; (17 pag.)CN110305128; (2019); A;,
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