Reference of 15862-30-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15862-30-3, name is 3-Bromo-5-nitropyridine, molecular formula is C5H3BrN2O2, molecular weight is 202.99, as common compound, the synthetic route is as follows.
To a flask was added 3-bromo-5-nitropyridine (60 mg, 296 mumol), THF (2 mL), tert-butyl pent-4-yn-1-ylcarbamate (59.6 mg, 325 mumol), Pd(OAc)2 (3.32 mg, 14.8 mumol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (17.1 mg, 29.6 mumol) and Cs2CO3 (193 mg, 591 mumol). Then the mixture was bubbled with N2 for 5 mins and heated to reflux (70 C. oil bath) for about 4.5 hours. The mixture was filtered through celite and the filtrate was concentrated to give a brown solid. After purification via combiflash (eluted with EA/PE=020%40%), tert-butyl N-[5-(5-nitro-3-pyridyl)pent-4-ynyl]carbamate (Compound 72A) was obtained as pale brown oil.
Statistics shows that 15862-30-3 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-nitropyridine.
Reference:
Patent; Hoffmann-La Roche Inc.; Hoves, Sabine; Wang, Lisha; Yun, Hongying; Zhang, Weixing; Zhu, Wei; (58 pag.)US2016/257653; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem