Synthetic Route of 168173-56-6 ,Some common heterocyclic compound, 168173-56-6, molecular formula is C6H5BrClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: 4-Amino-5,5-disubstituted furan-2(5H)-one 1a-e (2 mmol) was dissolved in dry MeCN (25 mL) in a 50-mL round-bottom flask. The solution was cooled to 0 C by an ice-water bath, then Cs2CO3 (1.304 g, 4 mmol) was added slowly. The mixture was warmed to r.t. and stirred for 4 h. ArCH2Cl 2a-h (2.4 mmol) was added and the mixture was stirred for 12 h under reflux. The mixture was cooled to r.t. and the solid material was filtered off. The filtrate was concentrated in vacuo and the crude product was purified by flash column chromatography (silica gel, 200-300 mesh, petroleum/EtOAc 4:1 to 3:2) to give compounds 3a-x and 4a-f.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,168173-56-6, its application will become more common.
Reference:
Article; Yu, Zhao; Xinlei, Liu; Weiwei, Wang; Rui, Geng; Wang, Mingan; Synthesis; vol. 50; 20; (2018); p. 4055 – 4062;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem