Reference of 59281-14-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 59281-14-0 as follows.
(B) 2-(Chloromethyl)-5-(phenylmethoxy)-4(1H)pyridinone, monohydrochloride A suspension of 2-(hydroxymethyl)-5-(phenylmethoxy)-4(1H)-pyridinone (3 g, 12.99 mmole) in chloroform (15 ml) was cooled to 0 under argon and treated with thionyl chloride (6.1 ml, 83.62 mmole). Within several minutes, a homogeneous solution was obtained. After stirring an additional 5 minutes, a cream colored solid precipitated. The cooling bath was removed and the mixture was heated at reflux for 45 minutes. The mixture was cooled to 0 and the white precipitate was filtered, washed with chloroform and hexane and dried in vacuo. The yield of the title compound was 3.65 g.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59281-14-0, its application will become more common.
Reference:
Patent; E. R. Squibb & Sons, Inc.; US4743685; (1988); A;,
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